Dump pretzels into a large bowl. Set aside. Preheat oven to 300 degrees F.
In a small saucepan melt the butter over low heat. Add hot sauce and simmer for 1 minute. Remove from heat and whisk in ranch dressing mix, seasoned salt and garlic powder. Drizzle the hot sauce mix over the pretzels and stir to coat completely.
Line a large baking sheet or two smaller baking sheets with parchment paper. Spread the pretzels in a single layer. Bake for 30 minutes, stirring every 10 minutes. Store in an airtight container for up to 3 weeks.